INHBA, inhibin subunit beta A, 3624

N. diseases: 83; N. variants: 1
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0042133
Disease: Uterine Fibroids
Uterine Fibroids 		0.300 Biomarker group CTD_human A high concentration of genistein down-regulates activin A, Smad3 and other TGF-β pathway genes in human uterine leiomyoma cells. 22228119 2012
CUI: C0042138
Disease: Uterine Neoplasms
Uterine Neoplasms 		0.300 Biomarker group CTD_human A high concentration of genistein down-regulates activin A, Smad3 and other TGF-β pathway genes in human uterine leiomyoma cells. 22228119 2012
CUI: C0032227
Disease: Pleural effusion disorder
Pleural effusion disorder 		0.100 Biomarker group HPO
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms 		0.040 Biomarker group BEFREE INHBA, which encodes a member of the TGF-beta superfamily of proteins, has been identified to play a critical role in different types of cancer. 29950896 2018
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms 		0.040 AlteredExpression group BEFREE Relative INHBA gene expression was measured in surgical specimens of cancer tissue and adjacent normal mucosa by quantitative real-time, reverse-transcription polymerase chain reaction. 24778035 2014
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms 		0.040 Biomarker group BEFREE In addition, knockdown of INHBA in cancer cells impaired cancer xenograft growth through reducing OC stromal fibroblast activation <i>in vivo.</i> Further results confirmed that Smad2 signaling pathway was involved in INHBA-induced stromal fibroblast activation, and inhibiting this pathway could effectively reverse activation of stromal fibroblasts. 31827640 2019
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms 		0.040 AlteredExpression group BEFREE In some cancer cell lines, the gene encoding activin A (inhibin βA [INHBA]) is over-expressed and enhances cancer proliferation. 20926007 2010
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm 		0.040 Biomarker group BEFREE In addition, knockdown of INHBA in cancer cells impaired cancer xenograft growth through reducing OC stromal fibroblast activation <i>in vivo.</i> Further results confirmed that Smad2 signaling pathway was involved in INHBA-induced stromal fibroblast activation, and inhibiting this pathway could effectively reverse activation of stromal fibroblasts. 31827640 2019
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm 		0.040 Biomarker group BEFREE INHBA, which encodes a member of the TGF-beta superfamily of proteins, has been identified to play a critical role in different types of cancer. 29950896 2018
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm 		0.040 AlteredExpression group BEFREE In some cancer cell lines, the gene encoding activin A (inhibin βA [INHBA]) is over-expressed and enhances cancer proliferation. 20926007 2010
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm 		0.040 AlteredExpression group BEFREE Relative INHBA gene expression was measured in surgical specimens of cancer tissue and adjacent normal mucosa by quantitative real-time, reverse-transcription polymerase chain reaction. 24778035 2014
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.020 AlteredExpression group BEFREE In clinical samples, ANLN and INHBA showed a significantly higher expression in tumors than in normal tissues. 17982635 2007
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.020 AlteredExpression group BEFREE In stage I AD patients, high levels of primary tumor INHBA transcripts were associated with worse prognosis. 19308293 2009
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma 		0.010 Biomarker group LHGDN Regulation of endometrial adenocarcinoma cell proliferation by Activin-A and its modulation by 17beta-estradiol. 12088879 2002
CUI: C0014170
Disease: Endometrial Neoplasms
Endometrial Neoplasms 		0.010 Biomarker group LHGDN Regulation of endometrial adenocarcinoma cell proliferation by Activin-A and its modulation by 17beta-estradiol. 12088879 2002
CUI: C0025517
Disease: Metabolic Diseases
Metabolic Diseases 		0.010 Biomarker group BEFREE The unique presence of serpin A3-7, coiled-coil domain containing 88A and inhibin/activin β A chain in HR-EXO, indicates potential biomarkers for cows at-risk for metabolic diseases. 31554846 2019
CUI: C0032914
Disease: Pre-Eclampsia
Pre-Eclampsia 		0.310 Biomarker phenotype CTD_human Oxidative stress increases placental and endothelial cell activin A secretion. 17332518 2007
CUI: C0032914
Disease: Pre-Eclampsia
Pre-Eclampsia 		0.310 AlteredExpression phenotype LHGDN Endothelial cells and peripheral blood mononuclear cells are a potential source of extraplacental activin a in preeclampsia. 14671202 2003
CUI: C0000731
Disease: Abdomen distended
Abdomen distended 		0.100 Biomarker phenotype HPO
CUI: C0000734
Disease: Abdominal mass
Abdominal mass 		0.100 Biomarker phenotype HPO
CUI: C0003962
Disease: Ascites
Ascites 		0.100 Biomarker phenotype HPO
CUI: C0013390
Disease: Dysmenorrhea
Dysmenorrhea 		0.100 Biomarker phenotype HPO
CUI: C0025323
Disease: Menorrhagia
Menorrhagia 		0.100 Biomarker phenotype HPO
CUI: C0027497
Disease: Nausea
Nausea 		0.100 Biomarker phenotype HPO
CUI: C0040038
Disease: Thromboembolism
Thromboembolism 		0.100 Biomarker phenotype HPO